Pre-Commercial Scale-Up

The objective of FHI's scale-up programme is to develop protocols for pre-commercial scale production of bioactive ingredients generated by the milk mining group.  Selected bioactive fractions will be taken through various stages of scale-up, which will involve processes for isolation, purification, concentration and preservation of ingredients under GMP conditions, for clinical evaluation or formulation in food products.  

A multi-disciplinary team involving researchers from Moorepark Food Research Centre (Teagasc) and University College Dublin will work to ensure that these processes are robust in terms of product consistency and that they conform to relevant quality/safety criteria for production in a manufacturing plant.  A diversity of expertise in separation and fractionation technologies is available at Moorepark to undertake the pre-commercial scale up, while at UCD the researchers will focus on identifying food preservation strategies to maintain the safety and efficacy of the bioactive ingredients.  

The scale-up group, currently being led by Dr Phil Kelly at Teagasc Moorepark, will work closely with researchers in the milk mining and health platforms to determine the technical and economic feasibility of producing the ingredients at a scale transferrable to the manufacturing industry.